描述
Benakor 20mg適用於治療犬充血性心臟衰竭。
活性物質：鹽酸貝那普利 20 mg。鹽酸貝那普利是一種前藥，在體內水解為其活性代謝物貝那普利拉。貝那普利拉是一種高效的選擇性 ACE 抑制劑，可防止無活性的血管緊張素 I 轉化為活性的血管緊張素 II，從而減少醛固酮的合成。因此，它可以阻斷血管緊張素 II 和醛固酮介導的作用，包括動脈和靜脈的血管收縮、腎臟的鈉和水瀦留以及重塑作用（包括病理性心臟肥大和腎退化性變化）。
劑量學和給藥途徑：獸藥應每天口服一次，可與食物同服或單獨服用。治療的持續時間是無限的。獸藥口服給藥的最小劑量為0.25mg（範圍0.25-0.5）鹽酸貝那普利/kg體重，每日一次，如下：
- 體重>20-40公斤：標準劑量0.5片；1 片，雙倍劑量。
- 體重>40-80公斤：標準劑量1片；2 片，雙倍劑量。
如果認為臨床有必要且獸醫建議的話，劑量可以加倍，繼續每天一次，最小劑量為0.5 mg/kg（範圍0.5-1.0）。如果使用半片藥片：將剩餘的一半藥片分開存放在泡罩中，並保存在溫度低於 25°C 的乾燥處。在下一劑中服用剩餘的一半藥片。
Benakor 20mg it is indicated for the treatment of congestive heart failure in dogs.
Active substances: Benazepril hydrochloride 20 mg.Benazepril hydrochloride is a pro-drug hydrolyzed in vivo in its active metabolite, benazeprilat. Benazeprilat is a highly potent selective ACE inhibitor, thus preventing the conversion of inactive angiotensin I into active angiotensin II and thus also reducing the synthesis of aldosterone. As such, it blocks the effects mediated by angiotensin II and aldosterone, including vasoconstriction of arteries and veins, sodium and water retention by the kidneys and remodeling effects (including pathological cardiac hypertrophy and degenerative renal changes).
Posology and route of administration:The veterinary medicinal product should be administered orally once a day, with or without food. The duration of treatment is unlimited.The veterinary medicinal product should be administered orally in a minimum dose of 0.25 mg (range 0.25-0.5) of benazepril hydrochloride / kg of body weight once daily, as follows:
- weight> 20-40 kg: 0.5 tablet in the standard dose; 1 tablet in double dose.
- weight> 40-80 kg: 1 tablet in the standard dose; 2 tablets in double dose.
The dose can be doubled, continuing to be administered once a day, at a minimum dose of 0.5 mg / kg (range 0.5-1.0), if considered clinically necessary and if the veterinarian advises so .In case of using halves of tablets: Store the remaining half of the tablet divided in the blister and keep in a dry place at temperatures below 25ºC. Administer the remaining half of the tablet in the next dose.
