Dechra 卡洛芬 NSAID 止痛片，牛肉口味，狗用卡洛芬牛肉味片具有鎮痛和抗發炎作用，可用於治療肌肉骨骼疾病和其他需要使用非類固醇抗發炎藥物的狗的病症。添加牛肉調味劑使給藥更容易。卡洛芬是一種非類固醇抗發炎藥 (NSAID)，用於治療發炎和鎮痛。卡洛芬對環氧合酶2 (COX-2) 同工酶的活性似乎比COX-1 更強，這可能部分解釋了為什麼卡洛芬似乎比許多其他NSAID 的潰瘍性更小。學口服給藥後，胃腸道有良好的吸收。蛋白質結合程度高，分佈體積小，主要分佈在細胞外位點。卡洛芬是一種弱酸，因此很容易滲透到發炎組織中。消除通常是在肝臟酵素代謝後進行，活性較低的代謝物會透過糞便和尿液排泄的組合而消除。原形藥物經尿排泄極少，依賴腎絲球濾過和腎小管排泄。還有一定程度的肝臟排泄和腸肝再循環的證據。Dechra Carprofen NSAID Pain Relief Tablet Beef Flavor for DogsCarprofen Beef Flavoured Tablets provides analgesic and anti-inflammatory actions for use in musculoskeletal disorders and other conditions where NSAIDs are indicated in dogs. The addition of beef flavouring makes administration easier.Carprofen is a nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of inflammation and to provide analgesia. Carprofen appears to have greater activity against the cyclooxygenase-2 (COX-2) isoenzyme than COX-1, which may partly explain why carprofen appears to be less ulcerogenic than many other NSAIDs.Pharmacokinetics There is good absorption from the gastrointestinal tract following oral administration. There is a high degree of protein binding and a small volume of distribution that is mostly to extracellular sites. Carprofen is a weak acid, so it readily penetrates into inflamed tissue. Elimination is usually following metabolism by hepatic enzymes, and the less active metabolites are eliminated via a combination of faecal and urinary excretion. Urinary excretion of the unchanged drug is minimal, and relies on glomerular filtration and tubular excretion. There is also a degree of hepatic excretion and evidence of enterohepatic recycling.
